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A model for the proposed role of Notch3 in hair cell differentiation. The conventional lateral inhibition cascade includes Dll and Jag2, the ligands expressed by the hair cell that would activate Notch1 in the adjacent supporting cells. On the other hand, Jag1 expressed by the supporting cell could be activating Notch3 in the hair cells and oppose the effects of Notch1 in this cell type, either by repressing the transcription of Hes5 or by promoting differentiation through Hes3.
