Fig. 3.

Kinetics of β₂m fibrillation. (A and E) Histograms of observed lag times. (B, D, and F) Thioflavin T fluorescence as a function of time showing kinetic traces for all samples in each group. (C) The average of all samples of each kind shown in D. (A and B) Forty micromolar β₂m at 37°C in 20 mM sodium phosphate buffer, pH 2.5, with 50 mM NaCl and 0.02% NaN₃. (C and D) Forty micromolar β₂m at 37°C in 20 mM sodium phosphate buffer, pH 2.5, with 40 mM NaCl and 0.02% NaN₃. (E and F) Forty micromolar β2m at 37°C in 20 mM sodium phosphate buffer, pH 2.5, with 50 mM NaCl and 0.02% NaN₃. Color coding of kinetic traces and histograms: blue (0.01 mg/ml 70-nm 85:15 NIPAM/BAM particles), cyan (0.01 mg/ml 200-nm 85:15 NIPAM/BAM particles), red (0.01 mg/ml 70-nm 50:50 NIPAM/BAM particles), pink (0.01 mg/ml 200-nm 50:50 NIPAM/BAM particles), orange (100 nM 16-nm quantum dots), green (≤0.01 mg/ml 6-nm-diameter multiwalled carbon nanotubes), yellow (≤0.01 mg/ml 16-nm cerium oxide particles), and black (samples without particles).