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. 2007 Mar 23;8(5):470–476. doi: 10.1038/sj.embor.7400945

Figure 4.

Figure 4

Ribbon representation of the Sulfolobus solfataricus exosome including a Corey–Pauling–Koltun model of the RNA bound in the structure. A possible path for RNA substrates is indicated by a magenta-coloured line. In this model, the 3′ end of the RNA substrate is recruited by the S1 pore of the Rrp4/Csl4 cap and then threaded through the neck of the central channel to the processing chamber, where it binds at one of the active sites and is degraded in a processive manner. Csl4, cep1 synthetic lethality; Rrp, ribosomal RNA processing factor.