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. Author manuscript; available in PMC: 2007 May 8.
Published in final edited form as: Hum Mol Genet. 2006 Mar 2;15(7):1087–1098. doi: 10.1093/hmg/ddl023

Figure 6.

Figure 6

AC can be activated by at least three distinct pathways: First, a novel NF1/Ras-dependent pathway stimulated by growth factors such as EGF and TGFα that activates an unidentified AC (AC-X), and does not involve Gαs; secondly, an NF1/Gαs-dependent pathway, acting through Rutabaga-AC (Rut-AC), stimulated by serotonin and histamine, and possibly PACAP38 (see discussion), that does not require Ras; thirdly, a classical NF1-independent pathway, involving Gαs but not NF1 or Ras, stimulated by FMRFamide and dopamine that activates an unidentified AC (AC-Y).