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. 2007 May 17;117(6):1527–1537. doi: 10.1172/JCI28338

Figure 4. Ephrin-B2–Fc increases EPC proangiogenic potential in hind limb ischemia.

Figure 4

(A) Representative photomicrographs and quantitative analysis of microangiography. (B) H&E staining and capillary density. CD31-positive capillaries appear in green. Scale bar: 100 μm. (C) Foot perfusion in mice injected with PBS, nonstimulated EPCs (EPCs), and stimulated EPCs (EPCs + ephrin-B2–Fc, EPC + EphB4-Fc, or EPC + CD6-Fc). Values are expressed as means ± SEM; n = 10 per group. **P < 0.01, ***P < 0.001 versus PBS-injected mice; ##P < 0.01, ###P < 0.001 versus nonstimulated EPC-injected mice. NI, nonischemic; Isch, ischemic.