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Mean ± SEM of AIA scores for (A) aggrecan loss at days 1, 3, and 5 (n = 5 per group); (B) aggrecan loss at days 7 (n = 35 [wild-type], 15 [Chloe], 32 [Jaffa]) and 28 (n = 49 [wild-type], 19 [Chloe], 21 [Jaffa]); and (C) cartilage erosion at days 7 and 28 (n as in B) in wild-type (white bars), Chloe (black bars), and Jaffa (gray bars) mice. *P < 0.05; **P < 0.01.
