Figure 7. Cartilage repair in Jaffa mice.

(A–F) Representative toluidine blue–stained sections of AIA joints from wild-type (A–C) or Jaffa (D–F) cartilage at day 28. A and D show no evidence of repair at day 28. Note the complete loss of toluidine blue in the articular cartilage (asterisks). Repair in wild-type (B and C) and Jaffa mice (E and F) at day 28 was seen predominantly in the femur. F, femoral surface; T, tibial surface. Arrowheads in C point to pericellular staining. Images in C and F are higher magnifications of the same sections shown in B and E. Scale bars: 100 μm. (G) Repair index, calculated as improvement in cartilage aggrecan loss score between days 7 and 28, in wild-type (n = 49; white bar), Chloe (n = 19; black bar), and Jaffa (n = 21; gray bar) femorotibial sections. Results are mean ± SEM. *P < 0.05.