TABLE 4.
Ventilatory and Gas Exchange Response to Acute Nitroprusside Infusion
| Variables | Baseline | Peak Nitroprusside | P-Value |
|---|---|---|---|
| VO2 (mL/min) | 266.1 ± 57.1 | 277.8 ± 50.9 | 0.59 |
| VCO2 (mL/min) | 226.2 ± 59.4 | 259.8 ± 56.4 | 0.14 |
| RER | 0.85 ± 0.07 | 0.93 ± 0.08 | 0.01 |
| VE (L/min) | 10.0 ± 2.3 | 11.6 ± 2.3 | 0.12 |
| VE/VCO2 | 44.8 ± 6.0 | 44.9 ± 6.0 | 0.94 |
| VT (mL/min) | 523.1 ± 172.5 | 716.1 ± 421.7 | 0.04 |
| RR (breaths/min) | 20.3 ± 5.1 | 19.2 ± 6.9 | 0.26 |
| PETO2 (mm Hg) | 97.9 ± 17.3 | 106.3 ± 6.5 | 0.05 |
| PETCO2 (mm Hg) | 32.6 ± 4.0 | 31.1 ± 3.6 | 0.02 |
| VD/VT | 0.47 ± 0.07 | 0.46 ± 0.06 | 0.31 |
| VT/TI | 515.2 ± 103.7 | 635.3 ± 125.8 | 0.01 |
| Amplitude of Ventilatory Oscillations (peak-nadir, L/min) | 5.5 ± 2.7 | 2.6 ± 2.4 | 0.001 |
| Amplitude of Ventilatory Oscillations (% of mean VE) | 57.5 ± 33.6 | 22.5 ± 20.8 | 0.001 |
| Cycle Length of Ventilatory Oscillations (sec) | 60.8 ± 17.6 | 41.4 ± 28.8 | 0.01 |
VO2, volume of oxygen consumed; VCO2, volume of carbon dioxide produced; RER, respiratory exchange ratio; VE, minute ventilation; VT, tidal volume; RR, respiratory rate; PETO2, partial pressure of end tidal oxygen; PETCO2, partial pressure of end tidal carbon dioxide. Data are presented as Mean±SD, n=12.