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. 1998 Dec;153(6):1873–1884. doi: 10.1016/S0002-9440(10)65701-X

Figure 5.

Figure 5.

Functional assays of macrophages after inhalation exposure of animals to particles and ozone. All data are presented as percentage of control. A: Nitric oxide production as determined by the assay of nitrite in 24-hour culture supernatants of macrophages stimulated with LPS. Results are expressed as mean ± SE; n = 12 to 18 animals. aEHC × OZONE factor interaction, P < 0.001. Tukey, 0 ppm versus 0.8 ppm O3 within 0 mg/m 3 EHC-93 and 0 mg/m3 versus 40 mg/m 3 EHC-93 within 0 ppm O3 (α = 0.05). B: TNF-α measured in 24-hour culture supernatants by ELISA. Results are expressed as mean ± SE; n = 5 to 12 animals. The DAYS main effect, P < 0.001, indicated overall higher amounts secreted for 1-day versus 3-day exposure groups. The data suggest a temporal pattern in the TNF-α response. C: MIP-2 was measured in 24-hour culture supernatants by ELISA. Results are expressed as mean ± SE; n = 9 to 10 animals. aEHC main effect, P = 0.035. D: ET-1 was measured in 24-hour cell culture supernatants by ELISA. Results are expressed as mean ± SE; n = 6 to 10 animals. aOZONE main effect, P < 0.001.