COILS prediction of SMC1 and SMC3 orthologs. The
COILS output for Homo sapiens SMC1 (a),
H. sapiens SMC3 (b) , Drosophila
melanogaster SMC1 (c), D. melanogaster SMC3
(d), fission yeast (Schizosaccharomyces pombe) SMC1
(e), fission yeast SMC3 (f), budding yeast
(Saccharomyces cerevisiae) SMC1 (g), and budding
yeast SMC3 (h) . The vertical axis denotes the probability of
the amino acid sequence adopting a coiled-coil structure based on a
scanning window of 28 residues. Although the original
COILS output included windows of 14 and 21 residues, these
have not been displayed for clarity. Conserved disruptions in the
coiled-coil structure prediction to the cohesin SMC sequences are
indicated beneath the COILS profile with an asterisk.