Figure 2.

Alignments of the disruptions in the predicted coiled-coil arms of cohesin and condensin SMC proteins. Disruptions to the first coiled-coil (a) and second coiled-coil (b, c) domains of SMC1, and first coiled-coil (d, e) and second coiled-coil (f) domains of SMC3 orthologs. Disruptions to the first coiled-coil (g) and second coiled-coil (h, i) domains of SMC4, and first coiled-coil (j, k) and second coiled-coil (l) domains of SMC2 orthologs. Regions with poor coiled-coil structure prediction are indicated by X's above the alignment. Right panels indicate the location of the sequence alignments presented in a–l on amino acid identity plots (window size, 8) generated from global co-alignment of the full-length SMC orthologous sequences from which alignments a–l are derived.