COILS prediction of SMC5 and SMC6 orthologs. The
COILS output for Homo sapiens SMC5 (a),
H. sapiens SMC6 (b), Drosophila melanogaster
SMC5 (c), C. elegans SMC6 (d), fission yeast
(Schizosaccharomyces pombe) Spr18 (e),
fission yeast Rad18 (f), budding yeast
(Saccharomyces cerevisiae) Spr18 ortholog
(g), and the budding yeast Rhc18 (h). The vertical
axis denotes the probability of the amino acid sequence adopting a
coiled-coil structure based on a scanning window of 28 residues.
Conserved disruptions in the coiled-coil structure prediction to the
SMC5/SMC6 SMC sequences are indicated beneath the COILS
profile with an asterisk.