Table 2.
Abundance of Microvessel Types in Tumors Produced in Estrogen- or Tamoxifen-Treated Mice by Parental or Transfected MCF-7 Cells
| Vessel Type | Treatment | Parental/control | MKL-F | MKL-4 | Clone 18 | MV165-14 |
|---|---|---|---|---|---|---|
| Edge associated | Estradiol | 0.84 ± 0.18 | 2.60 ± 0.24* | 1.25 ± 0.35 | 2.42 ± 0.44* | 0.71 ± 0.14 |
| Tamoxifen | 0.36 ± 0.08† | 2.30 ± 0.33* | 1.17 ± 0.42 | 1.92 ± 0.41* | 1.14 ± 0.29 | |
| Intratumor | Estradiol | 1.23 ± 0.19 | 2.65 ± 0.66 | 2.07 ± 0.50 | 2.00 ± 0.49 | 1.86 ± 0.30 |
| Tamoxifen | 0.83 ± 0.13 | 3.05 ± 0.41* | 2.17 ± 0.42* | 2.07 ± 0.54* | 2.61 ± 0.30* | |
| Ectatic stromal | Estradiol | 1.09 ± 0.18 | 1.40 ± 0.53 | 1.14 ± 0.39 | 1.71 ± 0.51 | 1.29 ± 0.19 |
| Tamoxifen | 1.45 ± 0.25 | 1.90 ± 0.60 | 0.83 ± 0.31 | 1.86 ± 0.29 | 1.25 ± 0.21 | |
| Normal stromal | Estradiol | 1.75 ± 0.19 | 2.40 ± 0.51 | 1.96 ± 0.50 | 2.71 ± 0.43 | 1.68 ± 0.25 |
| Tamoxifen | 1.89 ± 0.25 | 2.70 ± 0.37 | 1.96 ± 0.57 | 2.21 ± 0.42 | 2.14 ± 0.27 |
Microvessel score averages ± SEM are given for the various microvessel types from tumor sections harvested from mice treated with estrogen or tamoxifen pellets from time points 5 days or later after tumor cell injection.
*Scores significantly different from the parental cell scores for a particular treatment.
†Scores of tumors in tamoxifen treated animals receiving control cells differed significantly from those receiving estrogen treatment.