Table 3.
Immunophenotype of Large (Neoplastic) B Cells in T-Cell-Rich Large-B-Cell Lymphomas
| Case | Age (Years) | Sex | Apoptag | p53 | Bcl-2 | Mib-1 (Ki-67) | CD95 (fas) |
|---|---|---|---|---|---|---|---|
| 1 | 55 | M | 1+ | 0 | NR | 1+ | 3+ |
| 2 | 66 | M | 0 | 1+ | 1+ | 1+ | 3+ |
| 3 | 42 | F | 1+ | 1+ | 0 | 1+ | 2+ |
| 4 | 18 | F | 2+ | 3+ | 0 | 2–3+ | 1+ |
| 5 | 68 | F | 1+ | 1–2+ | 0 | 2+ | 1+ |
| 6 | 74 | M | 0 | 1+ | 1+ | 1+ | 1+ |
| 7 | 44 | F | 1+ | 3+ | 0 | 4+ | 3+ |
| 8 | 47 | M | 1–2+ | 1+ | 0 | 2+ | 1+ |
| 9 | 69 | M | 1+ | 0 | NR | 1+ | 1+ |
| 10 | 56 | F | 1+ | 0 | 0 | 1+ | 1+ |
| 11 | 67 | F | 0 | 1+ | 0 | 1+ | 1+ |
| 12 | 57 | M | 1+ | 3+ | 0 | 2+ | 1+ |
| 13 | 52 | M | 1+ | 0 | 1+ | 3+ | 1+ |
| 14 | 36 | M | 1+ | 2+ | 0 | 1+ | 1+ |
| 15 | 36 | F | 1+ | 1+ | 0 | 1+ | 1+ |
| 16 | 18 | M | 1+ | 1+ | 2+ | 4+ | 0 |
| 17 | 92 | F | 1+ | 1+ | 1+ | 1+ | 1+ |
| 18 | 43 | M | 1+ | 1+ | 1+ | 2+ | 1+ |
Patients 10 and 12 represent relapsed lymphomas with a TCRBCL pattern, occurring 8 and 7 years, respectively, after an initial diagnosis of DLBCL. (See also Tables 2 and 4 ▶ ▶ footnotes.) Results are shown based on the following scoring system: 0, no large cells marking; 1+, 1% to 10% large cells marking; 2+, 11% to 25% large cells marking; 3+, 26% to 50% large cells marking; 4+, >51% large cells marking. NR, tissue nonreactive with antibody (confirmed on repeat staining); M, male; F, female.