Table 3.

Distribution of HPV Genotypes in Three Different Patient Groups

HPV type	Patient group 1 (n = 534)		Patient group 2 (n = 304)		Patient group 3 (n = 184)
	Normal cytology ASCUS*	Mild or moderate dyskaryosis	Mild or moderate dyskaryosis	Severe dyskaryosis	Carcinoma
High risk	70 (59.8%)	27 (79.4%)	140 (95.2%)	150 (98.7%)	177 (96.2%)
Low risk	23 (19.7%)	6 (19.7%)	5 (3.4%)	0	1 (0.5%)†
Unknown‡	24 (20.5%)	1 (3.0%)	2 (1.4%)	2 (1.3%)	6 (3.3%)
Total	117	34	147	152	184

HPV genotypes were recognized in HPV-positive cases by sequence analysis of the SPF1/2 22-bp interprimer region and compared with published L1 region sequences of defined HPV genotypes. HPV genotypes 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 66, and 69 were considered as high-risk genotypes. HPV genotypes 6, 11, 34, 40, 42, 43, 44, 52, 54, 55, 59, 61, 62, 67, 68, 71, and 74 were considered as low-risk genotypes. 8

*Of the 160 SPF-positive cases in group 1, 9 samples, classified as no diagnosis possible, severe dyskaryosis, and carcinoma were excluded.

^†Sequence of the 22-bp interprimer region from this case was identical to HPV genotype 55.

^‡Sequences of the 22-bp interprimer region not exactly matching any published L1 sequence of a defined HPV genotype.