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. 2002 Aug;12(8):1257–1268. doi: 10.1101/gr.129702

Table 2.

Summary of Suggestive and Significant Linkages

Markera Position Populationd Mode of inheritancee LODf % of Phenotypical variance explainedg Allele increasing phenotypical score
MITb MGDc
3% Ethanol intake
D4Mit42 76.5 81.0 Males B6-dominant 2.65* 14.7 B6
D8Mit95 6.6 8.0 Males Additive 1.92* 11.1 B6
D9Mit25 20.8 26.0 Males 129-dominant 2.61* 17.6 B6
D12Mit46 13.1 17.0 Both genders B6-dominant 2.75* 8.5 129
D17Mit6 27.3 31.0 Both genders 129-dominant 3.13* 8.3 129
D18Mit55 16.4 25.0 Both genders Additive 2.24* 7.0 B6
3% Ethanol preference
D2Mit12 50.3 50.3 Both genders 129-dominant 2.22* 6.0 129
D8Mit95 6.6 8.0 Males Additive 3.65** 19.3 B6
D17Mit6 27.3 31.0 Both genders 129-dominant 2.09* 5.6 129
10% Ethanol intake
D4Mit256 82.0 82.7 Both genders B6-dominant 4.47** 13.3 B6
D7Mit69 20.8 24.5 Both genders B6-dominant 4.37** 11.8 129
10% Ethanol preference
D2Mit168h 66.7 81.7 Both genders Additive 1.94* 5.4 129
D4Mit256 82.0 82.7 Both genders B6-dominant 2.92* 8.7 B6
D13Mit147 37.2 51.0 Both genders Additive 1.93* 5.3 B6
a

Marker showing the strongest linkage. 

b

MIT—MIT/Whitehead Institute database (http://www-genome.wi.mit.edu/). 

c

MGD—Mouse Genome Database at The Jackson Laboratory (http://www.informatics.jax.org/). 

d

Only one gender is shown when linkage was above significant or suggestive threshold for this gender, but not for the other gender or for the combined sample of both genders. Note that linkage for distal chromosome 4 is present in both genders for 10% ethanol intake and preference (D4Mit256) and is male-specific for 3% ethanol intake (D4Mit42). 

e

Estimated based on LOD scores calculated using MAPMAKER/QTL under unconstrained, additive, recessive, and dominant models. 

f

LOD, logarithm of the odds ratio. Estimated for the most likely mode of inheritance. 

g

Estimated for the unconstrained model. 

h

For 10% ethanol preference, peak LOD score on chromosome 2 was at the agouti coat color locus (LOD 2.2, explained 6.6% of phenotypical variance, unconstrained model), but because this is a dominant marker (genotypes AA and Aa cannot be distinguished), mode of inheritance for this QTL was assessed based on genotype of another linked marker, D2Mit168. 

*

Suggestive linkage (LOD thresholds 1.9 for additive and 2.0 for dominant/recessive models). 

**

Significant linkage (logarithm of the odds ratio (LOD) thresholds 3.3 for additive and 3.4 for dominant/recessive models).