Table 1.
MCMV-MIE-lacZ Expression in Transgenic Mice with Reference to HCMV-MIE-lacZ Transgenic Mice
| System and organ | MCMV | HCMV | |
|---|---|---|---|
| −1343/−6 | −670/+54 | −584/−16 | |
| Brain | |||
| Cerebrum | + | + | + |
| Cerebellum | + | + | + |
| Gastrointestinal | |||
| Esophagus | − | + | +/− |
| Stomach | + | +/− | +/− |
| Small intestine | − | − | + |
| Colon | − | − | +/− |
| Liver | −∼+ | − | − |
| Salivary gland | −∼+ | + | +/− |
| Pancreas | −∼+ | + | − |
| Genitourinary | |||
| Kidney | + | + | + |
| Bladder | − | + | + |
| Testes | − | + | + |
| Ovary | − | + | +/− |
| Respiratory | |||
| Lung | − | − | − |
| Circulatory | |||
| Heart | −∼+ | + | + |
| Lymphoid and Blood | |||
| Spleen | − | + | + |
| Thymus | − | +/− | +/− |
| Bone marrow | − | + | |
| Blood | − | − | − |
| Lymph node | − | +/− | + |
| Endocrine gland | |||
| Adrenal gland | − | +/− | |
| Thyroid | − | +/− | +/− |
| Others | |||
| Smooth muscle | − | + | |
| Skeletal muscle | + | + |
Expression activity of MCMV MIE promoter (−1343/−6) was detected by x-Gal staining or immunostaining with anti β-Gal Ab. Expression activity of HCMV MIE promoter (−670/+54) was detected by x-Gal staining or immunostaining with anti β-Gal Ab. 16 Transcription activity of the HCMV IE promoter (−584/−16) was detected by Northern blotting. 18 +, positive; −, negative; −∼+, a portion of cells were positive; +/−, positive or negative.