Figure 12.
Shows in vitro uptake of C. parvum by peritoneal macrophages via scavenger receptors in the early stage of phagocytosis. A: Compared with MSR-A-expressing macrophages, the uptake of C. parvum by MSR-A-deficient macrophage was significantly reduced. B: MSR-A-expressing and MSR-A-deficient macrophages show no difference in uptake of nonopsonized C. parvum. Compared with untreated macrophages, macrophages with Fcγ II receptor blocking show significant reductions in uptake of opsonized C. parvum in both MSR-A+/+ and MSR-A−/− mice. □, untreated; ▪, blocked with 2.4G2. Data are mean ±SD of three assays.