. 2003 Dec 31;4(Suppl 1):S21. doi: 10.1186/1471-2156-4-S1-S21

Table 2.

Weighted segregation analysis of slopes*

	Hypothesis

			Mendelian

Segregation Parameter	General		Codominant		Dominant		Recessive		Additive		No Major Gene
	Estimate	SE	Estimate	SE	Estimate	SE	Estimate	SE	Estimate	SE	Estimate	SE

Intercept	3.205	0.1814	3.500	0.1932	3.790	0.2246	4.139	0.1489	3.744	0.2081	4.265	0.1485
β_cohort	-3.541	0.2393	-3.819	0.2094	-3.785	0.2092	-3.788	0.2143	-3.793	0.2090	-3.726	0.2113
β_Sex	-1.621	0.1981	-1.623	0.1965	-1.584	0.2001	-1.682	0.1907	-1.580	0.1897	-1.620	0.1936
β_AA	16.614	1.7795	16.625	2.4421	6.742	1.2112	14.296	2.1622	12.821	2.1109	—	—
β_Aa	4.443	0.5003	3.525	0.8312	6.742^A	—	0.000^B	—	6.411^C	—	—	—
q_A	0.199	0.0584	0.110	0.0265	0.042	0.0195	0.130	0.0269	0.047	0.0188	—	—
σ²	0.485	0.1782	1.849	0.5964	2.384	0.7088	3.384	0.5886	2.206	0.5857	4.949	0.6492
τ_aa	0.000	0.0000	0.000^D	—	0.000^D	—	0.000^D	—	0.000^D	—	—	—
τ_Aa	0.390	0.0694	0.500^D	—	0.500^D	—	0.500^D	—	0.500^D	—	—	—
τ_AA	0.000	0.0000	1.000^D	—	1.000^D	—	1.000^D	—	1.000^D	—	—	—

-2(log-likelihood)	17811.58		17824.66		17839.45		17828.49		17837.35		17867.83
p-value^E	—		< 0.001		< 0.001		< 0.001		< 0.001		< 0.001
AIC^F	17831.58		17838.66		17851.45		17840.49		17849.35		17875.83

*The outcome being modeled in equation (2) is 1000 × b_i, the subject-specific slope from equation (1). ^AConstrained to equal β_AA. ^BConstrained to equal 0. ^CConstrained to equal 1/2 β_AA. ^DParameter value is fixed. ^Ep-value based on a likelihood ratio test with the general model as the base model.^FAIC = -2(log-likelihood) + 2(number of free parameters).