Figure 2.

GENSCAN predictions from orthologous segments of mouse and human DNA do not closely correspond. Human and mouse sequences (1.8 and 1.3 Mb, respectively) were masked, and repeat sequences were removed to provide a closer correspondence in sequence length (1047 and 975 kb) for purposes of illustration. The first 277 kb of each sequence is shown here. This segment contains 84 conserved segments (based on BLAST2 sequence analysis with expected score ≥3e-18), but only 34 of 121 GENSCAN predicted human exons overlap one of these conserved sequences (indicated by black lines connecting the human and mouse sequence; only 20 diagonal lines appear because not all of the 34 matches resolve at this scale).