Figure 1.

A band karyotype of a metaphase from a 30-week-old c-myc/TGF-α double-transgenic mouse liver tumor demonstrating deletion of chromosome 1 band C4 and E, loss of chromosome 2, deletion and loss of chromosome 4, deletion of chromosome 7, a deletion of 17, and loss of the X chromosome. Chromosome 12 has a deletion of band D1 and a fusion of the deleted copy at the centromere resulting in a metacentric chromosome. The major breakpoints on chromosomes 1, 4, 5, 7, 9, and 12 and the loss of the X chromosome are indicated by arrows. A balanced translocation 5;6 identified by FISH is only partially detected by G-banding as a terminal deletion of 5, but the translocated material on 6 is not discernible.