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Histologic grading of cartilage from femoral condyles and tibial plateaus of OA dogs. Values are the mean (± SE) total score (Mankin scale) of lesions from 4-week OA rabbits; 8-week OA rabbits injected with the control plasmid; 8-week OA rabbits treated with 500 μg of IL-1Ra plasmid; 8-week OA rabbits treated with 1000 μg of IL-1Ra plasmid. P values were calculated using the two-tailed Student’s t-test and compared to the 8-week OA group.
