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Representative sections of synovium from (A) a 4-week OA rabbit and (B) an 8-week OA rabbit injected with the control plasmid, (C) an 8-week OA rabbit treated with 500 μg of IL-1Ra plasmid and, (D) an 8-week OA rabbit treated with 1000 μg of IL-1Ra plasmid. Hematoxylin and eosin staining; original magnification, ×250.
