Figure 2.

Enhanced lung vascular leakage 12 to 36 hours after CLP in the presence or absence of a direct lung insult (intrapulmonary deposition of IgG immune complexes (IC) or intratracheal instillation of LPS). The lung vascular permeability index, referred to in this and in subsequent figures as vascular leakage, was assessed by measuring the extravasation of intravenously administered ¹²⁵I-labeled BSA for 4 hours in the immune complex model and 6 hours in the LPS model. Open bars represent negative control groups; hatched bars represent positive controls. Calculations of percent change were determined by first subtracting the negative control values from the positive control groups. See text for details. For this and all subsequent groups, n ≥ 5.