Figure 5.

VEGFR-3 in invasive ductal (A-C) and lobular (D) breast cancer. The intratumoral VEGFR-3 positive vessels (A) surround tumor cell clusters in ductal breast carcinoma and are predominantly positive for PAL-E (black arrows in B). Also an invasive growth pattern is associated with VEGFR-3 positive vessels (C), whereas no staining is observed using anti-VEGFR-3 antibodies blocked with a 10-fold molar excess of the VEGFR-3 protein (inset in C). Occasionally, invasion of the carcinoma cells into the VEGFR-3 positive vessels could be observed (D). Magnification, ×200.