Figure 6.

Tumor homogenates from PC-3 tumor-bearing animals treated with anti-IL-8 show less angiogenic activity than NGS-treated tumor homogenates. PC-3 tumor-bearing mice that were treated with either goat anti-human IL-8 or NGS as a control were sacrificed, and tumor homogenates were analyzed in the rat corneal micropocket assay. A demonstrates the neovascular response seen in six of six eyes tested from the NGS-treated mice. B represents the neovascular response seen when the anti-IL-8 treated tumor homogenates were analyzed. In the anti-IL-8 treated mice, two of six eyes tested were negative, three of six showed only an occasional loop as seen in B, and one of six eyes tested was positive.