Table 1.

Mutational and Clinical Data of the Craniosynostotic Patients Included in the Study

Craniosynostotic conditions	Clinical features	FGFR mutations and locations
Apert syndrome	Acrocephaly, proptosis, mid-facial hypoplasia, severe bilateral bony and cutaneous syndactily of both hands and feet	P253R
		FGFR2, linker between the II and III Ig-like domains
Pfeiffer type II syndrome	Cloverleaf skull, mid-facial hypoplasia, severe ocular proptosis, digit anomalies	C342R
		FGFR2, III Ig-like domain
Nonsyndromic craniosynostosis	Coronal stenosis, plagiocephaly, hypertelorism and invaginated occipital bone	No canonic FGFR mutations (NCM)