Table 1.
Distribution of Several Clinicopathological Characteristics of CRCs According to the Presence of MSI
| Total | MSI− (n = 37) | MSI+ (n = 18) | p-value | |
|---|---|---|---|---|
| Age (mean± SD) | 65.1± 12.1 | 51.4± 17.9 | 0.004* | |
| Sex | ||||
| Males | 35 | 26 (70.3%) | 9 (50.0%) | |
| Females | 20 | 11 (29.7%) | 9 (50.0%) | 0.2† |
| Site | ||||
| Proximal | 28 | 13 (35.1%) | 15 (83.3%) | |
| Distal | 27 | 24 (64.9%) | 3 (16.7%) | <0.001† |
| Grading | ||||
| Well | 6 | 5 (13.5%) | 1 (5.6%) | |
| Moderate | 37 | 29 (78.4%) | 8 (44.4%) | |
| Poor | 12 | 3 (8.1%) | 9 (50.0%) | 0.002† |
| Duke’s | ||||
| A | 7 | 6 (16.2%) | 1 (5.6%) | |
| B | 29 | 18 (48.6%) | 11 (61.1%) | |
| C | 16 | 11 (29.7%) | 5 (27.8%) | |
| D | 3 | 2 (5.4%) | 1 (5.6%) | 0.7† |
| Mucinous histotype | ||||
| No | 42 | 31 (83.8%) | 11 (61.1%) | |
| Yes | 13 | 6 (16.2%) | 7 (38.9%) | 0.09† |
| Peritumor lymphoid nodules | ||||
| Absent | 13 | 12 (32.4%) | 1 (5.6%) | |
| Present | 42 | 25 (67.6%) | 17 (94.4%) | 0.04† |
| HLA class I heavy chain | ||||
| 0–25% | 2 | 1 (2.7%) | 1 (5.5%) | |
| 25–50% | 22 | 15 (40.5%) | 7 (38.9%) | |
| >50% | 31 | 21 (56.8%) | 10 (55.6%) | 0.9† |
| β2-microglobulin | ||||
| 0–25% | 3 | 1 (2.7%) | 2 (11.1%) | |
| 25–50% | 16 | 10 (27%) | 6 (33.3%) | |
| >50% | 36 | 26 (70.3%) | 10 (55.6%) | 0.2† |
*Wilcoxon rank sum test.
†Fisher’s exact test.