Table 3.

Effects of IL-1β on Steady-State Abundance of MMP, TIMP, and Cathepsin S mRNAs

Transcript	Fold change in mRNA abundance compared to controls
MMP-1	6.7 ± 2.7
MMP-3	37.3 ± 2.6
MMP-9	2.7 ± 0.1
TIMP-1	1.2 ± 0.1
TIMP-2 (3.5 kb)	0.6 ± 0.2
TIMP-2 (1 kb)	1.0 ± 0.3
Cathepsin S	34.0 ± 14

Northern blot analyses were carried out on CSMC cultured for 48 hours in the absence or presence of IL-1β (10 ng/ml). Values presented are fold-changes in mRNA abundance over control values, which were arbitrarily set to 1.0. Values are means ± SE from three independent experiments.