Table 2.

Mutations and LOH of Fas Gene in Malignant Melanomas

Case No.	LOH analysis				Codon	Mutation site	Nucleotide change	Predictive effect
	PA	PB	3	7
5	NI	LOH	NI	NI	241	Exon 9	963 G to A	Ala → Thr
9	–	NI	NI	NI	250	Exon 9	991 A to G	Asn → Ser
20	NI	NI	NI	NI	251	Exon 9	993 G to A	Val → Ile
11*	LOH	–	NI	NI
12*	LOH	NI	NI	NI
16*	LOH	NI	NI	NI
24*	LOH	NI	NI	NI
25*	LOH	NI	NI	NI
28*	LOH	LOH	NI	NI
29*	–	LOH	NI	NI
36*	LOH	–	NI	NI
37*	NI	NI	LOH	–
39*	LOH	–	NI	NI

LOH, loss of heterozygosity; NI, not informative.

*Cases with LOH and without somatic mutation of Fas.