Figure 6.

Dose-response curve of excised gas lung volume (ELGV) in response to aerosolized methacholine in control (unexposed to ovalbumin) mice. Mice inhaled a single concentration of methacholine, and measurements of retained air were made on their excised lungs. Methacholine elicited dose-dependent air trapping in control mice, with significantly increased ELGV values at 30 and 300 mg/ml (P < 0.01). ELGV is expressed in terms of mg of air/kg of body weight; data represent mean ± SEM values, with three to six mice in each group.