Figure 4.

Following intradermal injection of CD4+ T cell, numerous CD4+ T cells are present in the hyperplastic epidermis with only rare CD8+ T cells in the epidermis and diffuse keratinocyte HLA-DR expression. Following intradermal injection of CD8+ T cells, only rare scattered CD4+ T cells in the dermis are seen as well as CD4+ Langerhans cells in the epidermis. Upper dermal collections of CD8+ T cells include HLA-DR-positive mononuclear cells and focal epidermal keratinocyte HLA-DR expression.