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. 1999 Jul;155(1):39–46. doi: 10.1016/S0002-9440(10)65096-1

Figure 2.

Figure 2.

Par-4 is present in neurons in the brains of monkeys infected with a chimeric strain of HIV and simian immunodeficiency virus and in patients with HIV encephalitis. Formalin-fixed paraffin sections from the hippocampal formation of a SHIV-infected macaque with encephalitis (A), a patient with AIDS dementia (B), and an uninfected macaque (C) were immunostained with Par-4 antibody (see Methods). Many Par-4-immunoreactive cells with neuronal morphology are present in the tissue from the SHIV-infected monkey (black; this section was counterstained with hematoxylin) and the HIV encephalitis patient (this section was not counterstained), whereas no Par-4-immunoreactive cells are present in the hippocampal tissue from the uninfected control monkey. These sections are representative of results obtained in analyses of sections from three HIV encephalitis patients, three SHIV-infected macaques, two human control patients, and two uninfected monkeys.