Table 3.

Associations of MSI with Clinicopathological Features

Feature	Status	MSS	MSI-L	MSI-H	P value*
		(n = 98)	(n = 9)	(n = 10)
BAT-26	Stable	98	9	0	<0.001
	Instable	0	0	10
Age	Median (range)	66 (44–80)	70 (51–77)	70 (53–88)	0.436†
Gender	Male	71	8	6	0.348
	Female	27	1	4
Stage‡	I/II	37	2	7	0.038
	III/IV	61	7	3
Grade	Good	10	3	0	0.151
	Moderate	34	0	6
	Poor	54	6	4
Histology§	I	71	8	9	0.523
	D	26	1	1
	Mixed	1	0	0
Location	Proximal	34	4	0	0.022
	Mid/distal	64	5	10
Region¶	N.A.	68	9	4	0.036
	Italy	30	0	6
Pathological features∥		(n = 15)	(n = 5)	(n = 8)
Mucin/intra**	Neg	11	3	8	0.081
	Pos	4	2	0
Mucin/extra††	Neg	12	5	6	0.533
	Pos	3	0	2
Crohn’s-like reaction‡‡	Neg	8	2	2	0.111
	Pos	3	1	4
	N/A	4	2	2
Growth pattern	Cribiform	3	1	0	0.393
	Solid	6	2	4
	Glandular	6	2	4
TIL‡‡	1	12	5	3	0.016
	2	1	0	4
	3	2	0	1
TIN§§	1	13	4	6	0.273
	2	2	1	1
	3	0	0	1
Necrosis	Minimal	12	4	6	0.771
	Overt	3	1	2

*Chi-square test for MSS + MSI-L versus MSI-H.

^†Wilcoxon rank-sum test.

^‡TNM stage according to AJCC criteria.³²

^§Histopathology according to Lauren’s classification: I = intestinal, D = diffuse.

^¶Region of sample collection. N.A., North America.

^∥The cases studied for IHC were also analyzed for these pathological features.

**Mucin production, either intracellularly (Intra) and/or extracellularly (Extra).

^††Crohn’s like reaction presence was scored as present (Pos) or absent (Neg) or not able to be determined from sample analyzed (N/A). This p-value excludes N/A cases.

^‡‡Tumor infiltrating lymphocytes (TIL) were scored on a scale of 0–4.

^§§Tumor infiltrating neutrophiles (TIN) were scored on a scale of 0–4.