Table 2.
Chromosome Localization of Genes Implicated in Platinum Resistance
| Genes involved in signal transduction pathways | Chromosome location |
|---|---|
| EGF 28 (epidermal growth factor) | 4q25 |
| CyclinB p34 29 | 5q12 |
| PKCθ 30,31 (protein kinase C) | 10p15 |
| CALM1 32 (calmodulin) | 14q24–31 |
| PKCβ 30,31 | 16p11 |
| HER2/NEU 33 | 17q21.2 |
| PKCα 30,31 | 17q22–23 |
| Genes involved in the recognition of DNA damage and repair | |
| TopoIIβ 26,34 | 3p24–25 |
| HMG2 35 | 4q31 |
| POLB 36,37 (DNA polymerase β) | 8p11.2 |
| DDB1 38 (DNA damage binding protein) (xeroderma pigmentosum E) | 11q12–13 |
| HMG1 39 (high mobility group protein 1) | 13q12 |
| TopoIIα 26,34 | 17q21–22 |
| ERCC1 40 (excision repair complementing defective in chinese hamster) | 19q13 |
| POLA 37 (DNA polymerase α) | Xp21–22 |
| HSSB 41 (human single-stranded DNA binding protein) | n/a |
| SSRP1 42 (structure specific recognition protein) | n/a |
| Other genes implicated in modulating cisplatin resistance | |
| JUN 30 | 1p31–32 |
| MLH1 43 | 3p21–23 |
| WAF1 44 (wildtype p53 activated fragment) | 6p21 |
| PMS2 43 (post meiotic segregation) | 7p22 |
| MDR1 26 (multidrug resistance) | 7q21 |
| MYC 45 | 8q24 |
| H-RAS 46 | 11p15 |
| GSTπ 47 | 11q13 |
| MDM2 48 | 12q14–15 |
| FOS 49 | 14q24 |
| MRP 26,34 (multidrug resistance protein) | 16p13 |
| LRP 34 (lung resistance protein) | 16p11 |
| Metallothioneins 50 | 16q13 |
| p53 44,48 | 17p13 |
| ERBB2 51 | 17q21 |
| BCL2 52 | 18q21.3 |
| PLS3 53 (T-plastin) | n/a |
| HSP-60 54 (heat shock protein) | n/a |
| BCLX 55 | n/a |