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Lack of extracellular TGF-β1 in 3C7 mice. To visualize the TGF-β1 deposition in the ECM, tissue sections from 8-week-old mice were stained with polyclonal TGF-β antibodies specific for the intracellular (LC) or extracellular (CC) form of TGF-β1 (see Materials and Methods) and photographed at 200× magnification (+/+, wild-type mice; −/−, 3C7 mice with hypomorphic LTBP-4 alleles). Positive cells and matrix components are reddish-brown (arrows).
