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. 2002 Sep 1;16(17):2264–2273. doi: 10.1101/gad.229102

Figure 6.

Figure 6

Levels of large latent TGF-β1 complexes in 3C7 mice. Proteins from colon and kidney tissue digests (see Materials and Methods) were separated on denaturing polyacrylamide gels under nonreducing conditions, transferred to nitrocellulose membranes, and reacted with anti-LTBP-4 (αLTBP-4) or anti-LAPβ1 (αLAPβ1) antibodies. (A) Free LTBP-4 (left panel) and large latent LTBP complexes (right panel) in the colonic ECM of wild-type (+/+) and mutant 3C7 (−/−, hypomorphic LTBP-4 alleles) mice. (B) Levels of large latent LTBP complexes in the colonic and renal ECMs of 3C7 mice.