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Increased cell proliferation and c-myc induction in the colon of 3C7 mice. Tissue sections were stained with polyclonal rabbit anti-mouse Ki-67 (top) or monoclonal anti-mouse c-myc antibodies (center and bottom) and photographed at 200× magnification (+/+, wild-type mice; −/−, 3C7 mice with hypomorphic LTBP-4 alleles). Positive cells are reddish-brown (arrows).
