Figure 8.

Semiquantitative evaluation of autoradiographic signals (silver grains) obtained with the TIMP-1 probe in CC cases (closed bars) and in normal mucosa (hatched bars) as outlined in Figure 3 ▶ . In comparison to normal control mucosa, the number of TIMP-1-expressing cells in general (A) and of cells with high specific transcript levels (B), and the average number of grains per labeled cell (C) is increased in CC. The relative frequency of sSEMF cells with strong MMP-1- and TIMP-1-specific labeling is similar. Note that these cells display a clustered distribution (Figure 5) ▶ .