Table 2.
Clinicopathological, Immunohistochemical, and Genetic Characteristics of 13 Endometrioid Carcinomas
Case | Age | Stage | Grade | Endometriosis | ETLMP | Squamous metaplasia | β-Catenin pattern | Expression membrane | Mutated codon | Base change | Amino acid change | Follow-up (years) |
---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | 61 | 1c | 1 | Absent | Present | Present | Nuclear | Reduced | 32 | GAC to GGC | Asp to Gly | NED 6 |
2 | 49 | 1b | 1 | Absent | Present | Present | Nuclear | Preserved | 32 | GAC to TAC | Asp to Tyr | NED 6 |
3 | 47 | 1b | 2 | Absent | Absent | Present | Nuclear | Reduced | 32 | GAC to TAC | Asp to Tyr | NED 16 |
4 | 50 | 2b | 2 | Absent | Absent | Present | Nuclear | Reduced | 33 | TCT to TGT | Ser to Cys | NED 11 |
5 | 48 | 1a | 1 | Absent | Present | Present | Nuclear | Preserved | 37 | TCT to TGT | Ser to Cys | NED 8 |
6 | 64 | 2a | 1 | Present | Present | Present | Nuclear | Preserved | 37 | TCT to TTT | Ser to Phe | NED 11 |
7 | 50 | 2a | 2 | Present | Absent | Present | Nuclear | Preserved | 41 | ACC to GCC | Thr to Ala | NED 12 |
8 | 38 | 1c | 2 | Present | Present | Present | Nuclear | Reduced | NS | NED 22 | ||
9 | 58 | 1c | 3 | Absent | Absent | Absent | Nuclear | Reduced | NS | NED 14 | ||
10 | 66 | 2c | 2 | Present | Absent | Absent | Membranous | Reduced | NS | NED 6 | ||
11 | 49 | 1c | 2 | Absent | Absent | Absent | Membranous | Reduced | NS | DD 2 | ||
12 | 61 | 2c | 2 | Absent | Absent | Absent | Membranous | Reduced | NS | DD 2 | ||
13 | 27 | 1a | 3 | Absent | Absent | Absent | Membranous | Reduced | NS | DD 3 |
Endometriosis in case 10 affected the contralateral ovary, whereas the tumorous ovary was affected in cases 6, 7, and 8. This last case arose directly from a endometriotic cyst. ETLMP: Endometrioid tumor of low malignant potential. NS: normal sequence. NED: No evidence of disease. DD: Died of disease.