Table 1.
Microdissection-Based Genotyping for Allelic Imbalance: Pulmonary Tumorlet-Carcinoid Series
| Patient | Tumor type | Int-2 11q13.1 | p53 17p13.1 | VHL 3p25 | WT-1 11p13 |
|---|---|---|---|---|---|
| Carcinoid with tumorlets (3 patients noninformative for int-2) | |||||
| 1 | Carcinoid | + | − | − | − |
| Tumorlet | − | − | − | − | |
| 2 | Carcinoid | + | − | NI | NI |
| Tumorlet | − | − | NI | NI | |
| 3 | Carcinoid | + | − | NI | |
| Tumorlet | − | − | NI | ||
| 4 | Carcinoid | + | NI | − | |
| Tumorlet | − | NI | − | ||
| 5 | Carcinoid | − | |||
| (Tumorlet)* | |||||
| Carcinoid only (4 patients noninformative for int-2) | |||||
| 1 | Carcinoid | + | − | NI | − |
| 2 | Carcinoid | + | − | NI | − |
| 3 | Carcinoid | + | − | − | NI |
| 4 | Carcinoid | + | NI | ||
| 5 | Carcinoid | − | NI | ||
| 6 | Carcinoid | − | |||
| Tumorlet only (3 patients noninformative for int-2) | |||||
| 1 | Tumorlet | − | − | NI | − |
| 2 | Tumorlet | − | NI | NI | |
| 3 | Tumorlet | + | − | NI | |
| 4 | Tumorlet | − | − | − | NI |
| Tumorlet | − | − | − | NI | |
| 5 | Tumorlet | − | NI | − | |
| Tumorlet | − | NI | − |
*Seven tumorlets (one from the carcinoid and tumorlet group, six from the tumorlet-only group) identified on hematoxylin-eosin staining could not be found on recut unstained histological sections for microdissection genotyping. NI, Noninformative status for both gene polymorphisms.