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. 1999 Aug;155(2):349–353. doi: 10.1016/S0002-9440(10)65131-0

Figure 1.

Figure 1.

Results from the amplification of the BAT-26 locus in normal male lymphocyte DNA (Lane A), colorectal tumor DNA exhibiting MSI (Lane B), and lymphocyte DNA from five representative healthy African-Americans in three different PCR reactions (Lanes C-G). The banding pattern in Lane A shows the allelic profile of 26 adenine repeats previously described for BAT-26 in normal MSS DNA. Lane B (MSI-positive tumor) illustrates the characteristic banding pattern of MSI seen at BAT-26 in which one band corresponds to alleles with shortened mononucleotide repeats (lower band) compared to a second band demonstrating an allele of wild-type repeat length (upper band). Lane C and E depict the banding pattern seen in African-Americans with one allele of 26 repeats (upper bands) and one polymorphic 16-repeat allele (lower bands). Lanes F and G show the patterns seen in African-Americans with one 26 repeat allele (upper bands) and either a 22-repeat (Lane F) or a 4-repeat (Lane G) lower allele, respectively. Lane D shows the banding pattern from an African-American with both BAT-26 alleles within the previously described allelic profile.