Table 1.
Semiquantitative Analysis of the Pancreas of C57BI, MAM−/−, MUG1−/−, and MAM−/−MUG1−/− Mice
| Genotype | 66 hours of CDE diet | 120 hours of CDE diet | ||
|---|---|---|---|---|
| Score of necrosis | Number of mice (percentage) | Score of necrosis | Number of mice (percentage) | |
| C57BI | 0 | 3 (38) | 0 | 4 (22) |
| 1 | 4 (50) | 1 | 4 (22) | |
| 2 | 1 (12) | 2 | 3 (17) | |
| 3 | 0 (0) | 3 | 1 (6) | |
| 4 | 0 (0) | 4 | 6 (33) | |
| MAM−/− | 0 | 0 (0) | 0 | 1 (17) |
| 1 | 2 (40) | 1 | 2 (33) | |
| 2 | 2 (40) | 2 | 1 (17) | |
| 3 | 1 (20) | 3 | 2 (33) | |
| 4 | 0 (0) | 4 | 0 (0) | |
| MUG1−/− | 0 | 4 (57) | 0 | 1 (17) |
| 1 | 3 (43) | 1 | 2 (33) | |
| 2 | 0 (0) | 2 | 0 (0) | |
| 3 | 0 (0) | 3 | 0 (0) | |
| 4 | 0 (0) | 4 | 3 (50) | |
| MAM−/−MUG1−/− | 0 | 2 (33) | 0 | 0 (0) |
| 1 | 4 (67) | 1 | 0 (0) | |
| 2 | 0 (0) | 2 | 2 (33) | |
| 3 | 0 (0) | 3 | 0 (0) | |
| 4 | 0 (0) | 4 | 4 (67) |
The following score of necrosis was used: 0, normal morphology; 1, appearance of vacuoles; 2, minor areas of necrosis; 3, many areas of necrosis; 4, necrosis over the whole pancreas.