Table 1.
Clinicopathological Data and Immunohistochemical Detection of Nuclear β-Catenin Expression in 12 Hepatocellular Carcinomas with β-Catenin Gene Alterations
| Patient | Age/sex | Risk factor | Nontumoral liver | Tumor size (cm) | HCC grade | β-Catenin alterations | β-Catenin nu IS (%) |
|---|---|---|---|---|---|---|---|
| 1 | 73 /M | alcohol | cirrhosis | 9 | II | S45Y | 60 |
| 2 | 66 /M | alcohol | cirrhosis | 3 | II | H36P* | 8 |
| 3 | 60 /M | alcohol | fibrosis | 17 | II | S33P | 90 |
| 4 | 71 /M | alcohol | fibrosis | 12 | II | S45F | 0 |
| 5 | 63 /M | HCV | cirrhosis | 5 | I | G34E | 65 |
| 6 | 61 /F | HCV | cirrhosis | 3 | I | G34E | 75 |
| 7 | 55 /M | HBV | cirrhosis | 19 | I-II | T40A/I35N | 90 |
| 8 | 63 /M | hemochr | fibrosis | 4 | I | T41A | 75 |
| 9 | 59 /M | hemochr | normal | 9 | II | T41A/S47R | 20 |
| 10 | 64 /M | unknown | cirrhosis | 14 | II | D32A | 90 |
| 11 | 50 /M | unknown | normal | 14 | I | D20-144 | <1 |
| 12 | 42 /M | unknown | normal | 6 | I | D17-126 | <1 |
*Only one of four tumoral nodules in the liver of Patient 2 carried a β-catenin mutation.
HCV, hepatitis C virus infection; HBV, hepatitis B virus infection; hemochr, genetic hemochromatosis; nu IS, nuclear immunostaining; %, percentage of β-catenin-positive nuclei (among 1000 tumor cells counted).