Figure 7.

Comparison of human mac25/IGFBP-rP1 amino acid sequence with human, rat, and mouse hevin/SC1 sequences. A: Schematic representation of mac25/IGFBP-rP1 and hevin/SC1 proteins. The number of amino acids of each protein is indicated. Horizontal hatched lines, signal peptide; diagonal hatched lines, cysteine-rich domain including a follistatin-like module; black box, EF hand calcium-binding domain. B: Amino acid sequence alignment of the cysteine-rich domains of human mac25/IGFBP-rP1 and human, mouse, and rat hevin/SC1. Residues identical between the four sequences are colored in black, those conserved in gray. Dashed lines represent gaps introduced to align sequences.