Table 1.
Summary of Isolated HEV cDNAs
| Genes (no. of clones isolated) | Characteristics and functions |
|---|---|
| Matricellular proteins | |
| mac25/IGFBP-rP1 | Secreted growth factor and heparin binding protein |
| (1) | Modulates endothelial cell adhesion to type IV collagen |
| Hevin | SPARC-like protein |
| (3) | Modulates endothelial cell adhesion |
| Thrombospondin-1 | Angiogenesis inhibitor |
| (2) | Modulates endothelial cell adhesion |
| Chemokine receptor | |
| DARC | Promiscuous receptor for both CC and CXC chemokines |
| (1) | Receptor for the malaria parasite Plasmodium vivax |
| Mitochondrial proteins | |
| Cytochrome c oxidase 1 | Energy-transducing membrane protein |
| (13) | Involved in ATP synthesis |
| Cytochrome b | Subunit of complex III of the respiratory chain |
| (2) | Involved in ATP synthesis |