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Intraclonal diversity in a subset of PCNSL. PCR products of rearranged IgH genes were cloned in cases 4 (a), 8 (b), and 9 (c). Eight separate clones were analyzed in each case. Only those codons are shown in which sequence heterogeneity was observed. Dashes indicate sequence identity. Point mutations are labeled either as small letters for silent mutations or as capital letters for replacement mutations. gl, germline sequence.
