Table 1.
Clinical Data, as Well as Histopathological, Immunohistochemical, and in Situ Hybridization Findings
| Case number | Age (years) | Sex | Location | EBER† | MIB-1† |
|---|---|---|---|---|---|
| 1 | 51 | f | Temporal | − | +++ |
| 2 | 69 | f | Parieto-occipital | ± | +++ |
| 3 | 74 | f | Occipital | − | +++ |
| 4 | 65 | f | Temporal | − | +++ |
| 5 | 65 | m | Fourth ventricle* | − | +++ |
| 6 | 73 | f | Parietal* | − | ++ |
| 7 | 62 | f | Frontal | − | +++ |
| 8 | 49 | m | Frontal | − | ++ |
| 9 | 67 | f | Occipital | − | +++ |
| 10 | 61 | m | Frontal | − | +++ |
All tumors were CD20 positive and classified as malignant non-Hodgkin’s lymphoma of the diffuse large-cell lymphoma type; only the location of the biopsied lesion is given.
Abbreviations and symbols: f, female; m, male;
* cases with multifocal intracerebral manifestations.
†For the analysis of MIB-1 and Epstein-Barr virus (EBER)- positive cells, a grading system was used: −, negative; +, <20% of the tumor cells stained; ++, 20% to 50% of the tumor cells stained; +++, more than 50% of the tumor cells stained; ±, it could not be decided with certainty whether the EBER-positive cells represented tumor cells or were bystander lymphocytes.