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. 1999 Dec;155(6):2153–2165. doi: 10.1016/S0002-9440(10)65533-2

Figure 2.

Figure 2.

Performance of transgenic and wild-type mice in three sensorimotor tasks. a: Number of mice that fell off the walking rod during a 3-minute test period, expressed relative to the number of tested in each group. Compared to WT mice, significantly more 1H, 1HH, and 5HH mice fell down. *WT-1H: P < 0.001, O.R. 13.5 (40–4.6); WT-1HH: P < 0.001, O.R. 90 (1000–4.5); WT-5HH: P < 0.001, O.R. 5.4 (20.4–1.4). This motor impairment was shown to be gene dosage dependent. **5H-1HH: P < 0.001, O.R. 38.4 (1.8–1000); 5HH-1HH: P < 0.05, O.R. 17 (0.8–500); ***5H-1H: P < 0.001, O.R. 5.8 (1.6–20.8). b: Swimming speed defined as distance traveled in 1 minute. In the forced swimming test, 1HH mice (*) traversed a significantly shorter distance in 1 minute than wild-type and other transgenic mice (P < 0.001). 1H mice (**) performed even better than wild-type littermates (P < 0.05). c: Inverted wire grid hanging, expressed as number of mice that remained suspended for the entire 1-minute test period, relative to the number of mice tested in each group. Compared to wild-type mice, significantly more 1HH mice (*) failed to remain suspended on the inverted wire mesh grid. WT-1HH: P < 0.001, O.R. 22.2 (125–3.8). Number of mice tested is given in Materials and Methods. Asterisks do not denote significance levels, but indicate groups of mice to be compared. WT, wild-type mice; 1H and 1HH, heterozygous and homozygous htau40-1 mice, respectively; 5H and 5HH, heterozygous and homozygous htau40-5 mice, respectively. All mice were between 2 and 4 months old.