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. 1999 Dec;155(6):2153–2165. doi: 10.1016/S0002-9440(10)65533-2

Figure 4.

Figure 4.

Immunohistochemistry of brain and spinal cord of homozygous htau40 transgenic mice at 2.5 months. a: Low-power view of neocortex stained with monoclonal antibody AT-8, showing somatodendritic localization of tau protein in pyramidal neurons of layer V (×110). b: Reaction of monoclonal antibody MC-1 in neocortex with a neuron (arrowhead) and dystrophic neurites (arrows) (×800). c: Anterior horn of spinal cord, showing axonal dilations (arrows), dystrophic neurites (arrowheads), and a neuronal cell body staining with antibody MC-1 (×365). d: Neuron with axonal dilation (arrow), staining with the antibody SMI-32, directed to neurofilament (NF)-H. The proximal axon (small arrow) connecting the cell body (arrowhead) has a normal caliber (×600). e and f: Dilated axons (arrowheads) in thalamus immunostained for NF-L (e) and NF-M (f) (×305).